4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D). Treatment with chaperones has been associated with a decrease in endoplas...

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Foilsithe in:Sci Rep
Main Authors: de Pablo, Sara, Rodríguez-Comas, Júlia, Díaz-Catalán, Daniela, Alcarraz-Vizán, Gema, Castaño, Carlos, Moreno-Vedia, Juan, Montane, Joel, Parrizas, Marcelina, Servitja, Joan-Marc, Novials, Anna
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178353/
https://ncbi.nlm.nih.gov/pubmed/34088954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-91311-2
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