Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

OBJECTIVE: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D. Alpha1-antitrypsin (AAT) is a circulating protease in...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Rodríguez-Comas, Júlia, Moreno-Vedia, Juan, Obach, Mercè, Castaño, Carlos, de Pablo, Sara, Alcarraz-Vizán, Gema, Díaz-Catalán, Daniela, Mestre, Anna, Horrillo, Raquel, Costa, Montserrat, Novials, Anna, Servitja, Joan-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186564/
https://ncbi.nlm.nih.gov/pubmed/32229246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.100984
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