Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment

Human islet amyloid polypeptide (hIAPP) aggregation is associated with β-cell dysfunction and death in type 2 diabetes (T2D). we aimed to determine whether in vivo treatment with chemical chaperone 4-phenylbutyrate (PBA) ameliorates hIAPP-induced β-cell dysfunction and islet amyloid formation. Oral...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Montane, Joel, de Pablo, Sara, Castaño, Carlos, Rodríguez-Comas, Júlia, Cadavez, Lisa, Obach, Mercè, Visa, Montse, Alcarraz-Vizán, Gema, Sanchez-Martinez, Melchor, Nonell-Canals, Alfons, Parrizas, Marcelina, Servitja, Joan-Marc, Novials, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690378/
https://ncbi.nlm.nih.gov/pubmed/28821639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700236R
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