Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression

In type 2 diabetes, beta-cell dysfunction is thought to be due to several causes, one being the formation of toxic protein aggregates called islet amyloid, formed by accumulations of misfolded human islet amyloid polypeptide (hIAPP). The process of hIAPP misfolding and aggregation is one of the fact...

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Bibliografiska uppgifter
Huvudupphovsmän: Cadavez, Lisa, Montane, Joel, Alcarraz-Vizán, Gema, Visa, Montse, Vidal-Fàbrega, Laia, Servitja, Joan-Marc, Novials, Anna
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092029/
https://ncbi.nlm.nih.gov/pubmed/25010593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101797
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