Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression

In type 2 diabetes, beta-cell dysfunction is thought to be due to several causes, one being the formation of toxic protein aggregates called islet amyloid, formed by accumulations of misfolded human islet amyloid polypeptide (hIAPP). The process of hIAPP misfolding and aggregation is one of the fact...

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Bibliografiske detaljer
Main Authors: Cadavez, Lisa, Montane, Joel, Alcarraz-Vizán, Gema, Visa, Montse, Vidal-Fàbrega, Laia, Servitja, Joan-Marc, Novials, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092029/
https://ncbi.nlm.nih.gov/pubmed/25010593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101797
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