BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

OBJECTIVE: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effect on β-cells in different models of T2D. Thus, targeting BACE2 may represent a pot...

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Detalles Bibliográficos
Publicado en:Mol Metab
Main Authors: Díaz-Catalán, Daniela, Alcarraz-Vizán, Gema, Castaño, Carlos, de Pablo, Sara, Rodríguez-Comas, Júlia, Fernández-Pérez, Antonio, Vallejo, Mario, Ramírez, Sara, Claret, Marc, Parrizas, Marcelina, Novials, Anna, Servitja, Joan-Marc
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190493/
https://ncbi.nlm.nih.gov/pubmed/34015524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101251
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