Comprehensive mutational analysis of the BRCA1-associated DNA helicase and tumor suppressor, FANCJ/BACH1/BRIP1

FANCJ (BRIP1/BACH1) is a hereditary breast and ovarian cancer (HBOC) gene encoding a DNA helicase. Similar to HBOC genes, BRCA1 and BRCA2, FANCJ is critical for processing DNA inter-strand crosslinks (ICL) induced by chemotherapeutics, such as cisplatin. Consequently, cells deficient in FANCJ or its...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Calvo, Jennifer A, Fritchman, Briana, Hernandez, Desiree, Persky, Nicole S, Johannessen, Cory M, Piccioni, Federica, Kelch, Brian A., Cantor, Sharon B
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178215/
https://ncbi.nlm.nih.gov/pubmed/33619228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0828
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