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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations
BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between BRCA1 and BACH1, lead to defects in DNA repair, and result in breast and ovarian cancer. BACH1 is ne...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC356955/ https://ncbi.nlm.nih.gov/pubmed/14983014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308717101 |
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