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Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand

The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the chromosomal instability disorder Fanconi Anemia (FA). Understanding the roles of BACH1 in cellular D...

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Autori principali: Gupta, Rigu, Sharma, Sudha, Doherty, Kevin M., Sommers, Joshua A., Cantor, Sharon B., Brosh, Robert M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751539/
https://ncbi.nlm.nih.gov/pubmed/17145708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl964
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