A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Fanconi Anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer. Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase and mutations are also associated with breast and ovarian cancer. fancj(−/−) cells are sensitive to DNA interstrand cross-linking (ICL)...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Bharti, Sanjay Kumar, Sommers, Joshua A, Awate, Sanket, Bellani, Marina A, Khan, Irfan, Bradley, Lynda, King, Graeme A, Seol, Yeonee, Vidhyasagar, Venkatasubramanian, Wu, Yuliang, Abe, Takuye, Kobayashi, Koji, Shin-ya, Kazuo, Kitao, Hiroyuki, Wold, Marc S, Branzei, Dana, Neuman, Keir C, Brosh, Robert M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159516/
https://ncbi.nlm.nih.gov/pubmed/29788478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky403
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