FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange

Mutations in the FANCJ helicase predispose individuals to breast cancer and are genetically linked to the Fanconi anemia (FA) complementation group J. FA is a chromosomal instability disorder characterized by multiple congenital anomalies, progressive bone marrow failure, and high cancer risk. FANCJ...

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Detalhes bibliográficos
Main Authors: Sommers, Joshua A., Rawtani, Nina, Gupta, Rigu, Bugreev, Dmitry V., Mazin, Alexander V., Cantor, Sharon B., Brosh, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658046/
https://ncbi.nlm.nih.gov/pubmed/19150983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809019200
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