A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ line mutation impairs protein stability and function

PURPOSE: BRIP1 (FANCJ/BACH1), which encodes a DNA helicase that interacts with BRCA1, has been suggested to be a low penetrance breast cancer predisposing gene. We aimed to assess whether BRIP1 mutations contribute to breast cancer susceptibility in our population and, if so, to investigate the impa...

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Auteurs principaux: De Nicolo, Arcangela, Tancredi, Mariella, Lombardi, Grazia, Flemma, Chantal, Barbuti, Serena, Di Cristofano, Claudio, Sobhian, Bijan, Bevilacqua, Generoso, Drapkin, Ronny, Caligo, Maria Adelaide
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561321/
https://ncbi.nlm.nih.gov/pubmed/18628483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0087
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