Loss of the BRCA1-Interacting Helicase BRIP1 Results in Abnormal Mammary Acinar Morphogenesis

BRIP1 is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage–induced checkpoint control. Recent studies implicate BRIP1 as a moderate/low-penetrance breast ca...

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Detalhes bibliográficos
Main Authors: Daino, Kazuhiro, Imaoka, Tatsuhiko, Morioka, Takamitsu, Tani, Shusuke, Iizuka, Daisuke, Nishimura, Mayumi, Shimada, Yoshiya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765252/
https://ncbi.nlm.nih.gov/pubmed/24040146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074013
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