ATRT-08. TARGETING THE TP53-MDM2 ENHANCES RADIATION SENSITIVITY IN ATRT

Atypical Teratoid Rhabdoid Tumor is a highly aggressive pediatric brain tumor. Despite radiation, aggressive chemotherapy and autologous stem cell rescue, the children usually have poor survival. A functional genomic screen identified the TP53-MDM2 axis as a therapeutic vulnerability in ATRT. Gene e...

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Publicado en:Neuro Oncol
Autores principales: Alimova, Irina, Danis, Etienne, Wang, Dong, Pierce, Angela, Serkova, Natalie, Venkataraman, Sujatha, Vibahakar, Rajeev
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
Materias:
Atypical Teratoid Rhabdoid Tumors
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168153/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.007
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