ATRT-08. TARGETING THE TP53-MDM2 ENHANCES RADIATION SENSITIVITY IN ATRT

Atypical Teratoid Rhabdoid Tumor is a highly aggressive pediatric brain tumor. Despite radiation, aggressive chemotherapy and autologous stem cell rescue, the children usually have poor survival. A functional genomic screen identified the TP53-MDM2 axis as a therapeutic vulnerability in ATRT. Gene e...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Alimova, Irina, Danis, Etienne, Wang, Dong, Pierce, Angela, Serkova, Natalie, Venkataraman, Sujatha, Vibahakar, Rajeev
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2021
Ämnen:
Atypical Teratoid Rhabdoid Tumors
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168153/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.007
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk