ATRT-05. REPURPOSED ANTI-MALARIAL QUINACRINE ACTIVATES P53 AND INHIBITS ATRT TUMORIGENICITY

Atypical teratoid rhabdoid tumors (ATRTs) are fatal pediatric brain tumors that warrant improved therapies urgently. ATRTs are characterized by loss of INI1, a subunit of the SWI/SNF chromatin-remodeling complex. ATRTs grow aggressively despite majority of primary tumors expressing p53, suggesting i...

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Foilsithe in:Neuro Oncol
Main Authors: Kaur, Harpreet, Parthasarathy, Akhila, Guo, Huizi, Green, Peter C, Akhtarkhavari, Sepehr, Eberhart, Charles G, Raabe, Eric H
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2021
Ábhair:
Atypical Teratoid Rhabdoid Tumors
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168276/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.004
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