ATRT-23. THE DUAL mTORC1/2 INHIBITOR SAPANISERTIB DISRUPTS THE NRF2-MEDIATED STRESS RESPONSE AND COMBINES SYNERGISTICALLY WITH THE BH3 MIMETIC OBATOCLAX TO EXTEND AT/RT SURVIVAL

Atypical teratoid/rhabdoid tumors are aggressive infantile tumors highly resistant to intensive therapies. We aim to identify and target critical factors driving this therapy resistance to improve AT/RT survival. Analysis of publically available RNASeq on 32 AT/RT identified elevated expression of N...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Parkhurst, Ashlyn, Wang, Sabrina, Alt, Jesse, Arnold, Antje, Kaur, Harpreet, Slusher, Barbara, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Atypical Teratoid/Rhabdoid Tumors
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715807/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.022
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