ATRT-17. TARGETING GLUTAMINE METABOLISM LOWERS METHYLATION POTENCIALS IN AT/RT AND SYNERGIZE WITH TAZEMETOSTAT

Atypical teratoid/rhabdoid tumors (AT/RT) have a single recurring genetic mutation in SMARCB1. This deletion leads to an abnormal SWI/SNF chromatin remodeling complex and the constitutive activation of EZH2. S-adenosyl-L-methionine (SAM) donates a methyl group to EZH2 which then methylates DNA and h...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Nakata, Satoshi, Wang, Sabrina, Alt, Jesse, Slusher, Barbara, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Atypical Teratoid/Rhabdoid Tumors
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715146/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.016
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