ATRT-20. CDK7 INHIBITION IN AT/RT

Atypical teratoid/rhabdoid tumors (AT/RT) are characterized by loss-of-function mutations in the SMARCB1 component (and less commonly SMARCA4) of the SWI/SNF chromatin-remodeling complex. AT/RT demonstrate an overall silent genomic landscape with epigenetic dysregulation of the genome. CDK7 is a key...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Morin, Andrew, Veo, Bethany, Fosmire, Susan, Crespo, Michele, Zahedi, Shadi, Vibhakar, Rajeev, Levy, Jean M Mulcahy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Atypical Teratoid/Rhabdoid Tumors
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715874/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.019
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