ATRT-05. PRC1 IS AN ESSENTIAL DEPENDENCY AND THERAPEUTIC TARGET IN SMARCB1 DEFICIENT ATYPICAL TERATOID RHABDOID TUMORS

Atypical Teratoid Rhabdoid Tumors (ATRT) occur in young children with poor survival. ATRT are characterized by the absence of the chromatin remodeling protein SMARCB1 resulting in epigenetic dysregulation. To identify specific epigenetic factors essential for ATRT tumorigenesis, we performed a shRNA...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Alimova, Irina, Danis, Ettiene, Weetall, Marla, Pierce, Angelela M, Balakrishnan, Ilango, Wang, Dong, Foreman, Nicholas K, Baird, John, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.004
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