ATRT-06. ISPINESIB IS AN EFFICACIOUS THERAPEUTIC AGENT FOR ATYPICAL TERATOID RHABDOID TUMORS

BACKGROUND: Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and deadly embryonal brain tumor in children. KIF11 is needed for formation of the bipolar spindle in metaphase. KIF11 suppression leads to prolonged mitotic arrest and subsequent cell death in mitosis. KIF11 inhibitors are current...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ho, Jia-Min, Karthik, Sekar, M.F. Su, Jack, Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C, Adekunle, Adesina, Major, Angela, Erdreich-Epstein, Anat, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477369/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.005
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