ATRT-06. ISPINESIB IS AN EFFICACIOUS THERAPEUTIC AGENT FOR ATYPICAL TERATOID RHABDOID TUMORS

BACKGROUND: Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and deadly embryonal brain tumor in children. KIF11 is needed for formation of the bipolar spindle in metaphase. KIF11 suppression leads to prolonged mitotic arrest and subsequent cell death in mitosis. KIF11 inhibitors are current...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Ho, Jia-Min, Karthik, Sekar, M.F. Su, Jack, Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C, Adekunle, Adesina, Major, Angela, Erdreich-Epstein, Anat, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477369/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.005
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