ATRT-06. ISPINESIB IS AN EFFICACIOUS THERAPEUTIC AGENT FOR ATYPICAL TERATOID RHABDOID TUMORS

BACKGROUND: Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and deadly embryonal brain tumor in children. KIF11 is needed for formation of the bipolar spindle in metaphase. KIF11 suppression leads to prolonged mitotic arrest and subsequent cell death in mitosis. KIF11 inhibitors are current...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Ho, Jia-Min, Karthik, Sekar, M.F. Su, Jack, Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C, Adekunle, Adesina, Major, Angela, Erdreich-Epstein, Anat, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477369/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.005
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