ATRT-06. ISPINESIB IS AN EFFICACIOUS THERAPEUTIC AGENT FOR ATYPICAL TERATOID RHABDOID TUMORS

BACKGROUND: Atypical teratoid rhabdoid tumor (ATRT) is an aggressive and deadly embryonal brain tumor in children. KIF11 is needed for formation of the bipolar spindle in metaphase. KIF11 suppression leads to prolonged mitotic arrest and subsequent cell death in mitosis. KIF11 inhibitors are current...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Ho, Jia-Min, Karthik, Sekar, M.F. Su, Jack, Lin, Qi, Du, YuChen, Shen, Jianhe, Chow, Wing-Yuk, Lau, Ching C, Adekunle, Adesina, Major, Angela, Erdreich-Epstein, Anat, Elghetany, M Tarek, Hui, Kam-Man, Li, Xiaonan, Teo, Wan-Yee
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477369/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.005
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