ATRT-05. PRC1 IS AN ESSENTIAL DEPENDENCY AND THERAPEUTIC TARGET IN SMARCB1 DEFICIENT ATYPICAL TERATOID RHABDOID TUMORS

Atypical Teratoid Rhabdoid Tumors (ATRT) occur in young children with poor survival. ATRT are characterized by the absence of the chromatin remodeling protein SMARCB1 resulting in epigenetic dysregulation. To identify specific epigenetic factors essential for ATRT tumorigenesis, we performed a shRNA...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Alimova, Irina, Danis, Ettiene, Weetall, Marla, Pierce, Angelela M, Balakrishnan, Ilango, Wang, Dong, Foreman, Nicholas K, Baird, John, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.004
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