ATRT-05. PRC1 IS AN ESSENTIAL DEPENDENCY AND THERAPEUTIC TARGET IN SMARCB1 DEFICIENT ATYPICAL TERATOID RHABDOID TUMORS

Atypical Teratoid Rhabdoid Tumors (ATRT) occur in young children with poor survival. ATRT are characterized by the absence of the chromatin remodeling protein SMARCB1 resulting in epigenetic dysregulation. To identify specific epigenetic factors essential for ATRT tumorigenesis, we performed a shRNA...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Alimova, Irina, Danis, Ettiene, Weetall, Marla, Pierce, Angelela M, Balakrishnan, Ilango, Wang, Dong, Foreman, Nicholas K, Baird, John, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.004
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