ATRT-05. PRC1 IS AN ESSENTIAL DEPENDENCY AND THERAPEUTIC TARGET IN SMARCB1 DEFICIENT ATYPICAL TERATOID RHABDOID TUMORS

Atypical Teratoid Rhabdoid Tumors (ATRT) occur in young children with poor survival. ATRT are characterized by the absence of the chromatin remodeling protein SMARCB1 resulting in epigenetic dysregulation. To identify specific epigenetic factors essential for ATRT tumorigenesis, we performed a shRNA...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Alimova, Irina, Danis, Ettiene, Weetall, Marla, Pierce, Angelela M, Balakrishnan, Ilango, Wang, Dong, Foreman, Nicholas K, Baird, John, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.004
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