ATRT-05. PRC1 IS AN ESSENTIAL DEPENDENCY AND THERAPEUTIC TARGET IN SMARCB1 DEFICIENT ATYPICAL TERATOID RHABDOID TUMORS

Atypical Teratoid Rhabdoid Tumors (ATRT) occur in young children with poor survival. ATRT are characterized by the absence of the chromatin remodeling protein SMARCB1 resulting in epigenetic dysregulation. To identify specific epigenetic factors essential for ATRT tumorigenesis, we performed a shRNA...

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Publicat a:Neuro Oncol
Autors principals: Alimova, Irina, Danis, Ettiene, Weetall, Marla, Pierce, Angelela M, Balakrishnan, Ilango, Wang, Dong, Foreman, Nicholas K, Baird, John, Hoffman, Lindsey, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Atypical Teratoid Rhabdoid Tumor (ATRT)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477309/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.004
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