Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

X-box binding protein-1 (XBP1) is a transcription factor that plays a central role in controlling cellular responses to endoplasmic reticulum (ER) stress. Under stress conditions, the transcriptionally active form of XBP1 is generated via splicing of Xbp1 mRNA by the ER-resident protein inositol-req...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: Duwaerts, Caroline C., Siao, Kevin, Soon, Russell K., Her, Chris, Iwawaki, Takao, Kohno, Kenji, Mattis, Aras N., Maher, Jacquelyn J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166833/
https://ncbi.nlm.nih.gov/pubmed/33219328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00671-1
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