Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

X-box binding protein-1 (XBP1) is a transcription factor that plays a central role in controlling cellular responses to endoplasmic reticulum (ER) stress. Under stress conditions, the transcriptionally active form of XBP1 is generated via splicing of Xbp1 mRNA by the ER-resident protein inositol-req...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Duwaerts, Caroline C., Siao, Kevin, Soon, Russell K., Her, Chris, Iwawaki, Takao, Kohno, Kenji, Mattis, Aras N., Maher, Jacquelyn J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166833/
https://ncbi.nlm.nih.gov/pubmed/33219328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00671-1
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