IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells

In mammalian pancreatic β cells, the IRE1α–XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise role of this pathway, we constructed β cell–specific Ire1α conditional knockout (CKO) mice and established insulinoma cell lines in which Ire1α was...

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Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Tsuchiya, Yuichi, Saito, Michiko, Kadokura, Hiroshi, Miyazaki, Jun-ichi, Tashiro, Fumi, Imagawa, Yusuke, Iwawaki, Takao, Kohno, Kenji
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2018
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881499/
https://ncbi.nlm.nih.gov/pubmed/29507125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201707143
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