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IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
In mammalian pancreatic β cells, the IRE1α–XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise role of this pathway, we constructed β cell–specific Ire1α conditional knockout (CKO) mice and established insulinoma cell lines in which Ire1α was...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881499/ https://ncbi.nlm.nih.gov/pubmed/29507125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201707143 |
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