Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro

Upon endoplasmic reticulum (ER) stress, mammalian cells induce the synthesis of a transcriptional activator XBP1s to alleviate the stress. Under unstressed conditions, the messenger RNA (mRNA) for XBP1s exists in the cytosol as an unspliced precursor form, XBP1u mRNA. Thus, its intron must be remove...

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Bibliographische Detailangaben
Hauptverfasser: Shinya, Sayoko, Kadokura, Hiroshi, Imagawa, Yusuke, Inoue, Michihiro, Yanagitani, Kota, Kohno, Kenji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130286/
https://ncbi.nlm.nih.gov/pubmed/21398633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr132
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