Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway

Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress response. In metazoans, the unspliced form of X-box–binding protein 1 (XBP1u) m...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kanda, Satoshi, Yanagitani, Kota, Yokota, Yukiko, Esaki, Yuta, Kohno, Kenji
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056097/
https://ncbi.nlm.nih.gov/pubmed/27651490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604435113
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