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Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway
Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress response. In metazoans, the unspliced form of X-box–binding protein 1 (XBP1u) m...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056097/ https://ncbi.nlm.nih.gov/pubmed/27651490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604435113 |
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