Molecular Modelling Guided Design, Synthesis and QSAR Analysis of New Small Molecule Non-Lipid Autotaxin Inhibitors

The lysophospholipase D autotaxin (ATX) generates lysophosphatidic acid (LPA) that activates six cognate G-protein coupled receptors (GPCR) in cancerous cells, promoting their motility and invasion. Four novel compounds were generated aided by molecular docking guided design and synthesis techniques...

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Gepubliceerd in:Bioorg Chem
Hoofdauteurs: Banerjee, Souvik, Norman, Derek D., Deng, Shanshan, Fakayode, Sayo, Lee, Sue Chin, Parrill, Abby L., Li, Wei, Miller, Duane D., Tigyi, Gabor J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163515/
https://ncbi.nlm.nih.gov/pubmed/32890995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.104188
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