Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

BACKGROUND: While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Varma, Vijay R., Wang, Youjin, An, Yang, Varma, Sudhir, Bilgel, Murat, Doshi, Jimit, Legido-Quigley, Cristina, Delgado, João C., Oommen, Anup M., Roberts, Jackson A., Wong, Dean F., Davatzikos, Christos, Resnick, Susan M., Troncoso, Juan C., Pletnikova, Olga, O’Brien, Richard, Hak, Eelko, Baak, Brenda N., Pfeiffer, Ruth, Baloni, Priyanka, Mohmoudiandehkordi, Siamak, Nho, Kwangsik, Kaddurah-Daouk, Rima, Bennett, David A., Gadalla, Shahinaz M., Thambisetty, Madhav
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158920/
https://ncbi.nlm.nih.gov/pubmed/34043628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003615
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