Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

BACKGROUND: There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is critical to identifying novel targets for disease-mo...

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Publicat a:PLoS Med
Autors principals: Mahajan, Uma V., Varma, Vijay R., Griswold, Michael E., Blackshear, Chad T., An, Yang, Oommen, Anup M., Varma, Sudhir, Troncoso, Juan C., Pletnikova, Olga, O’Brien, Richard, Hohman, Timothy J., Legido-Quigley, Cristina, Thambisetty, Madhav
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980402/
https://ncbi.nlm.nih.gov/pubmed/31978055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003012
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