Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the role of brain cholesterol homeostasis in AD. W...

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Detalhes bibliográficos
Publicado no:NPJ Aging Mech Dis
Main Authors: Varma, Vijay R., Büşra Lüleci, H., Oommen, Anup M., Varma, Sudhir, Blackshear, Chad T., Griswold, Michael E., An, Yang, Roberts, Jackson A., O’Brien, Richard, Pletnikova, Olga, Troncoso, Juan C., Bennett, David A., Çakır, Tunahan, Legido-Quigley, Cristina, Thambisetty, Madhav
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169871/
https://ncbi.nlm.nih.gov/pubmed/34075056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-021-00064-9
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