Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the role of brain cholesterol homeostasis in AD. W...

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Bibliografski detalji
Izdano u:NPJ Aging Mech Dis
Glavni autori: Varma, Vijay R., Büşra Lüleci, H., Oommen, Anup M., Varma, Sudhir, Blackshear, Chad T., Griswold, Michael E., An, Yang, Roberts, Jackson A., O’Brien, Richard, Pletnikova, Olga, Troncoso, Juan C., Bennett, David A., Çakır, Tunahan, Legido-Quigley, Cristina, Thambisetty, Madhav
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8169871/
https://ncbi.nlm.nih.gov/pubmed/34075056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-021-00064-9
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