Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

BACKGROUND: While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Med
Egile Nagusiak: Varma, Vijay R., Wang, Youjin, An, Yang, Varma, Sudhir, Bilgel, Murat, Doshi, Jimit, Legido-Quigley, Cristina, Delgado, João C., Oommen, Anup M., Roberts, Jackson A., Wong, Dean F., Davatzikos, Christos, Resnick, Susan M., Troncoso, Juan C., Pletnikova, Olga, O’Brien, Richard, Hak, Eelko, Baak, Brenda N., Pfeiffer, Ruth, Baloni, Priyanka, Mohmoudiandehkordi, Siamak, Nho, Kwangsik, Kaddurah-Daouk, Rima, Bennett, David A., Gadalla, Shahinaz M., Thambisetty, Madhav
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158920/
https://ncbi.nlm.nih.gov/pubmed/34043628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003615
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