Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

BACKGROUND: While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with...

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Bibliografiset tiedot
Julkaisussa:PLoS Med
Päätekijät: Varma, Vijay R., Wang, Youjin, An, Yang, Varma, Sudhir, Bilgel, Murat, Doshi, Jimit, Legido-Quigley, Cristina, Delgado, João C., Oommen, Anup M., Roberts, Jackson A., Wong, Dean F., Davatzikos, Christos, Resnick, Susan M., Troncoso, Juan C., Pletnikova, Olga, O’Brien, Richard, Hak, Eelko, Baak, Brenda N., Pfeiffer, Ruth, Baloni, Priyanka, Mohmoudiandehkordi, Siamak, Nho, Kwangsik, Kaddurah-Daouk, Rima, Bennett, David A., Gadalla, Shahinaz M., Thambisetty, Madhav
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2021
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Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158920/
https://ncbi.nlm.nih.gov/pubmed/34043628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003615
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