Discovery of Dual Function Acridones as a Novel Antimalarial Chemotype

Preventing and delaying emergence of drug-resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both are undesirable in effective long-term strategies against multi-drug resistant (MDR) malaria. Heme remain...

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Gepubliceerd in:Nature
Hoofdauteurs: Kelly, Jane X., Smilkstein, Martin J., Brun, Reto, Wittlin, Sergio, Cooper, Roland A., Lane, Kristin D., Janowsky, Aaron, Johnson, Robert A., Dodean, Rozalia A., Winter, Rolf, Hinrichs, David J., Riscoe, Michael K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158239/
https://ncbi.nlm.nih.gov/pubmed/19357645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07937
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