Discovery of Dual Function Acridones as a Novel Antimalarial Chemotype

Preventing and delaying emergence of drug-resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both are undesirable in effective long-term strategies against multi-drug resistant (MDR) malaria. Heme remain...

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Pubblicato in:Nature
Autori principali: Kelly, Jane X., Smilkstein, Martin J., Brun, Reto, Wittlin, Sergio, Cooper, Roland A., Lane, Kristin D., Janowsky, Aaron, Johnson, Robert A., Dodean, Rozalia A., Winter, Rolf, Hinrichs, David J., Riscoe, Michael K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158239/
https://ncbi.nlm.nih.gov/pubmed/19357645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07937
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