Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of Drosophila expre...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Onur, Tarik Seref, Laitman, Andrew, Zhao, He, Keyho, Ryan, Kim, Hyemin, Wang, Jennifer, Mair, Megan, Wang, Huilan, Li, Lifang, Perez, Alma, de Haro, Maria, Wan, Ying-Wooi, Allen, Genevera, Lu, Boxun, Al-Ramahi, Ismael, Liu, Zhandong, Botas, Juan
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Assuntos:
Computational and Systems Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149125/
https://ncbi.nlm.nih.gov/pubmed/33871358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64564
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