Mutant Huntingtin in Glial Cells Exacerbates Neurological Symptoms of Huntington Disease Mice

Huntington disease (HD) is caused by an expansion of the polyglutamine (polyQ) repeat (>37Q) in huntingtin (htt), and age of onset is inversely correlated with the length of the polyQ repeat. Mutant htt with expanded polyQ is ubiquitously expressed in various types of cells, including glia, but c...

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Hlavní autoři: Bradford, Jennifer, Shin, Ji-Yeon, Roberts, Meredith, Wang, Chuan-En, Sheng, Guoqing, Li, Shihua, Li, Xiao-Jiang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856273/
https://ncbi.nlm.nih.gov/pubmed/20145253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083287
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