Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms

Many genetic mouse models of Huntington’s disease (HD) have established that mutant huntingtin (htt) accumulates in various subcellular regions to affect a variety of cellular functions, but whether and how synaptic mutant htt directly mediates HD neuropathology remains to be determined. We generate...

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Detalhes bibliográficos
Main Authors: Xu, Qiaoqiao, Huang, Shanshan, Song, Mingke, Wang, Chuan-En, Yan, Sen, Liu, Xudong, Gaertig, Marta A., Yu, Shan Ping, Li, He, Li, Shihua, Li, Xiao-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787372/
https://ncbi.nlm.nih.gov/pubmed/24081492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201303146
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