PEGylation near a patch of non-polar surface residues increases the conformational stability of the WW domain

Many proteins have one or more surface-exposed patches of non-polar residues; our observations here suggest that PEGylation near such locations might be a useful strategy for increasing protein conformational stability. Specifically, we show that conjugating a PEG-azide to a propargyloxyphenylalanin...

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Veröffentlicht in:J Org Chem
Hauptverfasser: Draper, Steven R. E., Ashton, Dallin S., Conover, Benjamin M., Carter, Anthony J., Stern, Kimberlee L., Xiao, Qiang, Price, Joshua L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147659/
https://ncbi.nlm.nih.gov/pubmed/31749365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02615
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