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How PEGylation Influences Protein Conformational Stability

PEGylation is an important strategy for enhancing the pharmacokinetic properties of protein therapeutics. The development of chemoselective side-chain modification reactions has enabled researchers to PEGylate proteins with high selectivity at defined locations. However, aside from avoiding active s...

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Pubblicato in:Curr Opin Chem Biol
Autori principali: Lawrence, Paul B., Price, Joshua L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107330/
https://ncbi.nlm.nih.gov/pubmed/27580482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2016.08.006
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