PEG-based Changes to β-sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location

The development of chemical strategies for site-specific protein modification now enable researchers to PEGylate a protein drug at one or more specific locations. However, aside from avoiding enzyme active sites or protein-binding interfaces-specific PEGylation, distinguishing the optimal PEGylation...

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Foilsithe in:Bioconjug Chem
Main Authors: Draper, Steven R. E., Lawrence, Paul B., Billings, Wendy M., Xiao, Qiang, Brown, Nathaniel P., Becar, Natalie A., Matheson, Derek J., Stephens, Andrew R., Price, Joshua L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330093/
https://ncbi.nlm.nih.gov/pubmed/28972368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00281
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