Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis

We previously showed that long-range stapling of two Asn-linked O-allyl PEG oligomers via olefin metathesis substantially increases the conformational stability of the WW domain through an entropic effect. The impact of stapling was more favorable when the staple connected positions that were far ap...

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Vydáno v:RSC Chem Biol
Hlavní autoři: Xiao, Qiang, Ashton, Dallin S., Jones, Zachary B., Thompson, Katherine P., Price, Joshua L.
Médium: Artigo
Jazyk:Inglês
Vydáno: RSC 2020
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009319/
https://ncbi.nlm.nih.gov/pubmed/33796855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cb00075b
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