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Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis
We previously showed that long-range stapling of two Asn-linked O-allyl PEG oligomers via olefin metathesis substantially increases the conformational stability of the WW domain through an entropic effect. The impact of stapling was more favorable when the staple connected positions that were far ap...
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| Опубликовано в: : | RSC Chem Biol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
RSC
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8009319/ https://ncbi.nlm.nih.gov/pubmed/33796855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cb00075b |
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