Conjugation Strategy Strongly Impacts the Conformational Stability of a PEG-Protein Conjugate

Site-specific PEGylation is an important strategy for enhancing the pharmacokinetic properties of protein drugs, and has been enabled by the recent development of many chemoselective reactions for protein side-chain modification. However, the impact of these different conjugation strategies on the p...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Lawrence, Paul B., Billings, Wendy M., Miller, McKenzie B., Pandey, Brijesh K., Stephens, Andrew R., Langlois, Minnie I., Price, Joshua L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082735/
https://ncbi.nlm.nih.gov/pubmed/27191252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00349
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