A carregar...
Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect
Hydrocarbon stapling and PEGylation are distinct strategies for enhancing the conformational stability and/or pharmacokinetic properties of peptide and protein drugs. Here we combine these approaches by incorporating asparagine-linked O-allyl PEG oligomers at two positions within the β-sheet protein...
Na minha lista:
| Publicado no: | Org Biomol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6290918/ https://ncbi.nlm.nih.gov/pubmed/30444518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02535e |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|