Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect

Hydrocarbon stapling and PEGylation are distinct strategies for enhancing the conformational stability and/or pharmacokinetic properties of peptide and protein drugs. Here we combine these approaches by incorporating asparagine-linked O-allyl PEG oligomers at two positions within the β-sheet protein...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Org Biomol Chem
Päätekijät: Xiao, Qiang, Bécar, Natalie A., Brown, Nathaniel P., Smith, Mason S., Stern, Kimberlee L., Draper, Stven R. E., Thompson, Katherine P., Price, Joshua L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290918/
https://ncbi.nlm.nih.gov/pubmed/30444518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02535e
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